Drug Interactions with Tioconazole, Terconazole and Miconazole

When taken in conjunction with one another, certain medications will interfere with others. Due to the chemical composition of some drugs, the ingredients react with one another to cause variety side effects, ranging from a mild result to a serious increase in potency that may be so toxic it becomes life threatening.


Terconazole, the generic of Terazol and Zazole, is an antifungal used as a topical cream or as a vaginal suppository, in order to treat candida alibicans. The drug works by stopping production of the fungus by weakening the membrane located around the yeast cell. Although terconazole may cause various side effects, such as site reactions, it is not known to interfere with any other drugs.


The drug Tioconazole is usually given in the form of a vaginal suppository or a topical cream. However, tablets and tampons infused with the medication are available, as well. This antifungal works in the same manner as terconazole—by weakening the membrane of the cell wall. The drug is not 100 percent safe to take when you have certain medical conditions, and it may cause a few side effects. On the other hand, it is not known to cause any form of reaction when combined with other drugs.


Miconazole may be administered using various methods, such as applying topically as a power, spray, lotion or cream. For vaginal yeast infections, it is available as a suppository to be interested in the vagina or as a cream to be applied in and/or around a woman’s vaginal region.

Miconazole may cause various side effects, including fever, stomach pain and application site reaction. It might also trigger a foul-smelling vaginal discharge. In addition to the side effects that can be constituted by the drug given alone, there are six major drug interactions known. Besides the serious interactions, 255 moderate interactions are known, as well as 29 minor reactions.

Anisindione, dicumarol and warfarin are both anticoagulants that do not mix well, when taken along with miconazole. When these drugs are given to the same patient, the miconazole elevates the plasma concentration of the anticoagulants. It also will hypoprothrombinemic effect of the warfarin.

Antihistamines like astemizole and terfenadine mixed with miconazole result in the plasma concentration of the antihistamines rising.

The plasma concentration statin drugs used to lower cholesterol will increase when combined with miconazole. The reaction is classified as a moderate interaction. All drugs in this category including simvastatin, atorvastatin and lovastatin have the potential to reaction, when co-administered.

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